Clinical significance of the advanced lung cancer inflammation index in patients with limited-stage small cell lung cancer treated with chemoradiotherapy

Clinical significance of the advanced lung cancer inflammation index in patients with limited-stage small cell lung cancer treated with chemoradiotherapy

The aim of the study was to investigate the prognostic significance of the advanced lung cancer inflammation index (ALI) in patients with limited-stage small-cell lung cancer (LS-SCLC) undergoing definite chemo-radiotherapy (CRT). We included 87 patients with LS-SCLC from South Korea, treated betwee...

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Veröffentlicht in:Scientific reports 2024-05, Vol.14 (1), p.10347-10, Article 10347
Hauptverfasser: Seo, Bo Mi, Choi, Jiin, Chang, Boksoon, Kim, Bo-Guen, Park, Tai Sun, Lee, Hyun, Moon, Ji-Yong, Kim, Sang-Heon, Kim, Tae-Hyung, Yoo, Seung-Jin, Park, Hae Jin, Yoon, Ho Joo, Sohn, Jang Won, Lee, Seung Hyeun, Park, Dong Won
Format: Artikel
Sprache:eng
Schlagworte:
631/67
631/67/1612
631/67/1857
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Body mass index
Chemoradiotherapy
Chemoradiotherapy - methods
Chemotherapy
Cisplatin
Cisplatin - administration & dosage
Cisplatin - therapeutic use
Clinical Relevance
Etoposide
Etoposide - administration & dosage
Etoposide - therapeutic use
Female
Humanities and Social Sciences
Humans
Inflammation
Irradiation
Leukocytes (neutrophilic)
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Lymphocytes
Male
Medical prognosis
Middle Aged
multidisciplinary
Multivariate analysis
Neoplasm Staging
Neutrophils
Prognosis
Radiation therapy
Retrospective Studies
Science
Science (multidisciplinary)
Small cell lung carcinoma
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - mortality
Small Cell Lung Carcinoma - pathology
Small Cell Lung Carcinoma - therapy
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Zusammenfassung:The aim of the study was to investigate the prognostic significance of the advanced lung cancer inflammation index (ALI) in patients with limited-stage small-cell lung cancer (LS-SCLC) undergoing definite chemo-radiotherapy (CRT). We included 87 patients with LS-SCLC from South Korea, treated between 2005 and 2019 with definite CRT. ALI was calculated using body mass index, serum albumin, and neutrophil–lymphocyte ratio. We categorized 38 patients into the high ALI group (ALI ≥ 44.3) and 48 into the low ALI group (ALI 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-61145-9