Targeting Long Noncoding RNA in Glioma: A Pathway Perspective

Targeting Long Noncoding RNA in Glioma: A Pathway Perspective

Long noncoding RNAs (lncRNAs) participate extensively in biological processes of various cancers. The majority of these transcripts are uniquely expressed in differentiated tissues or specific cancer types. lncRNAs are aberrantly expressed in gliomas and exert diverse functions. In this article, we...

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Veröffentlicht in:Molecular therapy. Nucleic acids 2018-12, Vol.13, p.431-441
Hauptverfasser: Li, Junyang, Zhu, Yihao, Wang, Handong, Ji, Xiangjun
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Apoptosis
biomarker
Biomarkers
Brain cancer
Cancer therapies
Cell adhesion & migration
Cell cycle
Cell growth
Feedback
Gene expression
Genomes
Glioma
Kinases
Localization
long noncoding RNA
Lung cancer
Medical prognosis
Metastasis
MicroRNAs
Motility
Ribonucleic acid
RNA
Tumorigenesis
Tumors
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Zusammenfassung:Long noncoding RNAs (lncRNAs) participate extensively in biological processes of various cancers. The majority of these transcripts are uniquely expressed in differentiated tissues or specific cancer types. lncRNAs are aberrantly expressed in gliomas and exert diverse functions. In this article, we provided an overview of how lncRNAs regulate cellular processes in glioma, enumerated the lncRNAs that may act as glioma biomarkers, and showed their potential clinical implications.
ISSN:2162-2531
2162-2531
DOI:10.1016/j.omtn.2018.09.023