EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES

When function of kidneys get disturbed then it might leads to increased potassium levels by various means such as increased potassium level due to decreased excretion by kidneys, movement of potassium outside the cell due to metabolic acidosis and retention of dietary potassium1. [...]to counter hyperkalemia Sodium polystyrene sulfonate (SPS) is frequently used either as a single agent or in combination with other drugs. [...]the effect of single dose of SPS has also been evaluated on other serum electrolytes. Serum electrolytes monitoring and assessment of acid-base balance is necessary in such high risk patients8. [...]concurrent administration oral SPS and nonabsorbable antacids/phosphate binders containing magnesium hydroxide, aluminum carbonate or calcium carbonate may produce an unexpected metabolic alkalosis. [...]the decrease in concentration of calcium and magnesium level were within the normal range, but still they require monitoring especially in patients with multiple cardiac risk and patient with renal impairment. [...]it is recommended that serum electrolytes as well as acid-base balance should be monitored closely in high risk patients.