The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets

Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the...

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Veröffentlicht in:Cells (Basel, Switzerland) Switzerland), 2024-10, Vol.13 (20), p.1685
Hauptverfasser: Snelders, Matthijs, Yildirim, Meltem, Danser, A H Jan, van der Pluijm, Ingrid, Essers, Jeroen
Format: Artikel
Sprache:eng
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Zusammenfassung:Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the remodeling of the heart, where compensatory changes in the extracellular matrix exacerbate disease progression. This review explores the processes and changes occurring in the pressure-overloaded heart with respect to the extracellular matrix. It further summarizes current treatment strategies, and then focuses on novel treatment targets for maladaptive cardiac remodeling, derived from transverse aortic constriction-induced pressure overload animal models.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13201685