Anti-fatigue effect of OM-X, fermented plant extract with lactic acid bacteria and bifidobacteria: A randomized, placebo-controlled, double-blind, comparative study

[Display omitted] •OM-X provides carbohydrates (oligosaccharides and dietary fiber), fats (short-chain fatty acids), proteins, amino acids, some vitamins, minerals, and polyphenols.•Recent studies have elucidated that the cause of fatigue in modern people is radical oxygen in the autonomic center system.•The 12-week ingestion of OM-X improved the VAS and Chalder fatigue scale. The comprehensive antioxidative ability (modified BAP/ d-ROMs ratio) increased.•Continuous intake of OM-X may ameliorate the feeling of fatigue for healthy people with temporary fatigue. The objective of this study is to elucidate how the OM-X made from many kinds of plants fermented using lactic acid bacteria (LAB) and bifidobacteria contributes to anti-fatigue. A randomized, placebo-controlled, double-blind, comparative study design was adopted. We investigated the effects of 12-week ingestion of the test food or placebo. Visual analogue scale (VAS) and Chalder fatigue scale (CFS) were examined to evaluate the feeling of fatigue, and diacron-reactive oxygen metabolites (d-ROMs) and Biological Antioxidant Potential (BAP) were measured to appraise comprehensive antioxidative ability. We also evaluated the safety of the food. As a result, significant differences between the two groups were detected in VAS and CFS. No safety-related matter occurred. It turned out that the ingestion of OM-X improved feelings of fatigue for healthy people with temporary fatigue. Additionally, there was no adverse effect by the ingestion of the food.