DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

Keywords: DDX3X mutation, Hematolymphoid malignancy, Prognosis, Tumour metastasis, Drug resistance

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer 2021-10, Vol.20 (1), p.134-134, Article 134
Hauptverfasser:	Kizhakeyil, Atish, Zaini, Nurmahirah Binte Mohammed, Poh, Zhi Sheng, Wong, Brandon Han Siang, Loh, Xinpeng, Ng, Aik Seng, Low, Zun Siong, Prasannan, Praseetha, Gong, Chun, Tan, Michelle Guet Khim, Nagarajan, Chandramouli, Huang, Dachuan, Lu, Pang Wan, Lim, Jing Quan, Barrans, Sharon, Ong, Choon Kiat, Lim, Soon Thye, Chng, Wee Joo, Follows, George, Hodson, Daniel J, Du, Ming Qing, Goh, Yeow Tee, Tan, Suat Hoon, Grigoropoulos, Nicholas Francis, Verma, Navin Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use B-cell lymphoma Biomarkers, Tumor Burkitt's lymphoma Cancer Care and treatment Cell adhesion Cell Line, Tumor Chemoresistance Cyclin D1 - genetics DDX3X mutation DEAD-box RNA Helicases - deficiency Disease Progression DNA helicase Drug resistance Drug Resistance, Neoplasm - genetics Gene regulation Genomes Hematolymphoid malignancy Humans Letter to the Editor Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - metabolism MAP kinase Medical prognosis Mitogen-Activated Protein Kinases - metabolism Mutation Non-Hodgkin's lymphoma Non-Hodgkin's lymphomas Phosphorylation Prognosis RNA helicase Signal transduction Stat3 protein STAT3 Transcription Factor - metabolism T cells Transcription Tumour metastasis Whole Exome Sequencing
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Beschreibung
Zusammenfassung:	Keywords: DDX3X mutation, Hematolymphoid malignancy, Prognosis, Tumour metastasis, Drug resistance
ISSN:	1476-4598 1476-4598
DOI:	10.1186/s12943-021-01437-0