Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo : The Knee Explant Analysis (KnEA) Study
PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from chronic periprosthetic joint infections ( = 17). At a concentration of 1 mg/mL for 15 min, there was a mean 4-log reduction (range, 1 to 7) in the...
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Veröffentlicht in: | Microbiology spectrum 2021-12, Vol.9 (3), p.e0187921-e0187921 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from chronic periprosthetic joint infections (
= 17). At a concentration of 1 mg/mL for 15 min, there was a mean 4-log
reduction (range, 1 to 7) in the bacterial CFU identified from the implants.
Chronically infected prosthetics of the knee were exposed to PLG0206, an engineered antimicrobial peptide, at a concentration of 1 mg/mL for 15 min. A mean 4-log
reduction (range, 1 to 7) in the number of bacteria occurred, which may translate to improved clinical outcomes for persons with prosthetic joint infection of the knee. |
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ISSN: | 2165-0497 2165-0497 |
DOI: | 10.1128/Spectrum.01879-21 |