Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis

We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels...

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Veröffentlicht in:	Arquivos de neuro-psiquiatria 2011-02, Vol.69 (1), p.91-99
Hauptverfasser:	Varella, Pedro Paulo Vasconcellos, Santiago, Joselita Ferreira Carvalho, Carrete, Jr, Henrique, Higa, Elisa Mieko Suemitsu, Yacubian, Elza Márcia Targas, Centeno, Ricardo Silva, Caboclo, Luís Otávio Sales Ferreira, Castro Neto, Eduardo Ferreira de, Canzian, Mauro, Amado, Débora, Cavalheiro, Esper Abrão, Naffah-Mazzacoratti, Maria da Graça
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amygdala - pathology citocinas Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - surgery esclerose hipocampal Female glutamato Glutamic Acid - analysis Hippocampus - chemistry Hippocampus - pathology Hippocampus - surgery Humans Inflammation Mediators - analysis Interleukin-1 - analysis Interleukin-1beta - analysis Leukocyte Common Antigens - analysis Magnetic Resonance Imaging - methods Male Middle Aged NEUROSCIENCES Nitric Oxide - analysis PSYCHIATRY Sclerosis sinal hipocampal em FLAIR Temporal Lobe - chemistry Temporal Lobe - pathology Tumor Necrosis Factor-alpha - analysis Young Adult
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Zusammenfassung:	We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p
ISSN:	0004-282X 1678-4227 1678-4227 0004-282X
DOI:	10.1590/S0004-282X2011000100018