Exploring the association of IL-10 polymorphisms in Behcet's disease: a systematic review and meta-analysis

Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet's disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD.A systematic literature se...

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Veröffentlicht in:	Journal of inflammation (London, England) England), 2019-12, Vol.16 (1), p.26-26, Article 26
Hauptverfasser:	Shahriyari, Elham, Vahedi, Leila, Roshanipour, Nasrin, Jafarabadi, Mohammad Asghari, Khamaneh, Amin, Laleh, Maryam Ghaffari
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Asymmetry B cells Behcet's syndrome Behçet’s disease Bias Binding sites Cytokines Disease Genes Genetic aspects Interleukin 10 Interleukins Medical research Meta-analysis Minority & ethnic groups Polymorphism Studies Systematic review Vein & artery diseases
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Zusammenfassung:	Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet's disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD.A systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications, and extracted the respective results. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the power of association with a random-effects model. A total of 19 articles, consisting of 10,626 patients and 13,592 controls were included in the meta-analysis. The meta-analysis revealed significant associations in allelic and genotypic test models of - 819 (C vs. T: OR = 0.691,
ISSN:	1476-9255 1476-9255
DOI:	10.1186/s12950-019-0230-2