Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study

Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study

The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants (n = 12) performed 300 eccentric leg extensions under control (Placebo) versus histamine H1 and H2 receptor antagonis...

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Veröffentlicht in:Physiological reports 2024-02, Vol.12 (3), p.e15936-n/a
Hauptverfasser: Ely, Matthew R., Mangum, Joshua E., Needham, Karen Wiedenfeld, Minson, Christopher T., Halliwill, John R.
Format: Artikel
Sprache:eng
Schlagworte:
Aerobics
antihistamine
Cytokines
Data collection
Exercise
Food
Histamine
Inflammation
Kinases
Leukocytes
leukocytosis
Monocyte chemoattractant protein 1
Musculoskeletal system
Physical fitness
Physiology
Placebos
Proteins
Skeletal muscle
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Zusammenfassung:The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants (n = 12) performed 300 eccentric leg extensions under control (Placebo) versus histamine H1 and H2 receptor antagonism (Blockade) in a randomized cross‐over study. Circulating leukocytes and cytokines were measured for 72 h after exercise. Circulating leukocytes were elevated at 6 and 12 h after exercise (p 
ISSN:2051-817X
DOI:10.14814/phy2.15936