PROTECTIVE LEVELS OF VARICELLA-ZOSTER ANTIBODY DID NOT EFFECTIVELY PREVENT CHICKENPOX IN AN X-LINKED AGAMMAGLOBULINEMIA PATIENT

We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-s...

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Veröffentlicht in:	Revista do Instituto de Medicina Tropical de São Paulo 2015-09, Vol.57 (5), p.455-457
Hauptverfasser:	Nobre, Fernanda Aimée, Gonzalez, Isabela Garrido da Silva, de Moraes-Pinto, Maria Isabel, Costa-Carvalho, Beatriz Tavares
Format:	Artikel
Sprache:	eng
Schlagworte:	Agammaglobulinemia Agammaglobulinemia - drug therapy Agammaglobulinemia - immunology Antibodies, Viral - blood Case Report Chickenpox Chickenpox - diagnosis Chickenpox - immunology Chickenpox - prevention & control Child Genetic Diseases, X-Linked - drug therapy Genetic Diseases, X-Linked - immunology Herpesvirus 3, Human - immunology Humans Immune Sera - administration & dosage Immunodeficiency disorders Immunoglobulin Immunoglobulin G - blood Intravenous Male Treatment Failure TROPICAL MEDICINE
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Zusammenfassung:	We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels. The case illustrates that IVIG may not prevent VZV infection.
ISSN:	0036-4665 1678-9946 1678-9946 0036-4665
DOI:	10.1590/S0036-46652015000500017