N-cyanomethylnorboldine: a new aporphine isolated from Alseodaphne perakensis (Lauraceae)

A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural eluci...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2011-04, Vol.16 (4), p.3402-3409
Hauptverfasser:	Nafiah, Mohd Azlan, Mukhtar, Mat Ropi, Omar, Hanita, Ahmad, Kartini, Morita, Hiroshi, Litaudon, Marc, Awang, Khalijah, Hadi, A Hamid A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alseodaphne perakensis aporphine alkaloid Aporphines - chemistry Aporphines - isolation & purification Aporphines - pharmacology Chemical Sciences Electronic mail systems Lauraceae Lauraceae - chemistry Magnetic Resonance Spectroscopy Molecular Structure Organic chemistry Spectrum Analysis - methods
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Beschreibung
Zusammenfassung:	A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules16043402