Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study

Background Prenatal alcohol exposure (PAE) is a worldwide public health concern. While PAE is known to be associated with low birth weight, little is known about timing and quantity of PAE on fetal growth. This study investigated the association between periconceptional and prenatal alcohol exposure and longitudinal fetal growth, focusing on timing and quantity in a high exposure cohort. Methods The Safe Passage Study was a prospective cohort study, including 1698 pregnant women. Two-dimensional transabdominal ultrasound examinations were performed to measure fetal femur length, abdominal and head circumference, and biparietal diameter, at three time points during pregnancy. Estimated fetal weight and Z-scores of all parameters were calculated. Trimester-specific alcohol exposure was assessed using the Timeline Followback method. To investigate the associations of specific timing of PAE and fetal growth, two models were built. One with alcohol exposure as accumulative parameter over the course of pregnancy and one trimester specific model, in which PAE was separately analyzed. Linear mixed models adjusted for potential confounders were applied with repeated assessments of both alcohol exposure and fetal growth outcomes. Results This study demonstrated that periconceptional and prenatal alcohol exposure were associated with reduced fetal growth. Effect sizes are displayed as estimated differences (ED) in Z-score and corresponding 95% confidence intervals (95% CIs). When investigated as accumulative parameter, PAE was related to a smaller femur length (ED.sub.30; - 0.13 (95% CI; - 0.22; - 0.04), ED.sub.36; - 0.14 (95% CI; - 0.25; - 0.04)) and a smaller abdominal circumference (ED.sub.36; - 0.09 (95% CI; - 0.18; - 0.01)). Periconceptional alcohol exposure was associated with a smaller abdominal circumference (ED.sub.30; - 0.14 (95% CI; - 0.25; - 0.02), ED.sub.36; - 0.22 (95% CI; - 0.37; - 0.06)) and a smaller estimated fetal weight (ED.sub.36; - 0.22 (95% CI; - 0.38; - 0.05)). Second trimester alcohol exposure was associated with a smaller abdominal circumference (ED.sub.30; - 0.49 (95% CI; - 0.86; - 0.12), ED.sub.36; - 0.70 (95% CI; - 1.22; - 0.17)) and estimated fetal weight (ED.sub.30; - 0.54 (95% CI; - 0.94; - 0.14), ED.sub.36; - 0.69 (95% CI; - 1.25; - 0.14)). No additional association of binge drinking was found besides the already observed association of PAE and fetal growth. Conclusions This study demonstrated that PAE negatively affects fetal growth,