Hypothermia Modulates Cytokine Responses After Neonatal Rat Hypoxic-Ischemic Injury and Reduces Brain Damage

While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic injury (HII), the mechanisms underlying its neuroprotective effect are poorly understood. We examined ischemic core/penumbra and cytokine/chemokine evolution in a 10-day-old rat pup model of HII. Pups were treated for...

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Veröffentlicht in:	ASN neuro 2014-11, Vol.6 (6), p.175909141455841
Hauptverfasser:	Yuan, Xiangpeng, Ghosh, Nirmalya, McFadden, Brian, Tone, Beatriz, Bellinger, Denise L., Obenaus, Andre, Ashwal, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Animals, Newborn Cytokines - metabolism Diffusion Magnetic Resonance Imaging Disease Models, Animal Hypothermia, Induced - methods Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - therapy Magnetic Resonance Imaging Movement Disorders - etiology Movement Disorders - prevention & control Neurologic Examination Original Rats Rats, Sprague-Dawley Regression Analysis
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Zusammenfassung:	While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic injury (HII), the mechanisms underlying its neuroprotective effect are poorly understood. We examined ischemic core/penumbra and cytokine/chemokine evolution in a 10-day-old rat pup model of HII. Pups were treated for 24 hr after HII with HT (32℃; n = 18) or normothermia (NT, 35℃; n = 15). Outcomes included magnetic resonance imaging (MRI), neurobehavioral testing, and brain cytokine/chemokine profiling (0, 24, 48, and 72 hr post-HII). Lesion volumes (24 hr) were reduced in HT pups (total 74%, p
ISSN:	1759-0914 1759-0914
DOI:	10.1177/1759091414558418