Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma Cell Proliferation

The search for natural anticancer agents and nanocarrier uses are a part of the current strategies to overcome the side effects caused by chemotherapeutics. Liposomal nanocapsules loaded with purified tarin, a potential immunomodulatory and antitumoral lectin found in taro corms, were produced. Lipo...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2019-01, Vol.24 (3), p.471
Hauptverfasser:	Corrêa, Anna C N T F, Vericimo, Mauricio A, Dashevskiy, Andriy, Pereira, Patricia R, Paschoalin, Vania M F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma antitumoral activity Bone marrow Brain cancer Breast Breast cancer Cancer therapies Cell proliferation chemotherapeutic adjuvant Chemotherapy Cisplatin Colocasia esculenta Corms Drug dosages Efficiency Encapsulation Entrapment entrapment efficiency Extrusion Folic acid food bioactive Glioblastoma Glycerol Immunomodulation Lectins Light scattering Morphology no-toxicity Photon correlation spectroscopy Polydispersity Polyethylene glycol preclinical tests Scanning electron microscopy Side effects Sonication stable nanocapsules tarin Thin films Toxicity
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Zusammenfassung:	The search for natural anticancer agents and nanocarrier uses are a part of the current strategies to overcome the side effects caused by chemotherapeutics. Liposomal nanocapsules loaded with purified tarin, a potential immunomodulatory and antitumoral lectin found in taro corms, were produced. Liposomes were composed by 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine, cholesterylhemisuccinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine- -[folate(polyethylene glycol)-2000 prepared by thin-film hydration. Small unilamellar vesicles were achieved by sonication and extrusion. Scanning electron microscopy evidenced round-shaped nanocapsules presenting a smooth surface, 150 nm diameter and polydispersity index
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules24030471