Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through t...

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Veröffentlicht in:JHEP reports 2024-08, Vol.6 (8), p.101132, Article 101132
Hauptverfasser: de Veer, Rozanne C., van Hooff, Maria C.B., Werner, Ellen, Beuers, Ulrich, Drenth, Joost P.H., Cuperus, Frans J.C., van Hoek, Bart, Veldt, Bart J., Klemt-Kropp, Michael, van Meer, Suzanne, Verdonk, Robert C., Flink, Hajo J., Vrolijk, Jan Maarten, Gevers, Tom J.G., Ponsioen, Cyriel Y., ter Borg, Martijn J., Soufidi, Khalida, Boersma, Femke, de Jonge, Hendrik J.M., Wolfhagen, Frank H.J., Baak, L.C., Onderwater, Susanne L., van Putten, Paul G., de Bruin, Gijs J., Adang, Rob P.R., de Boer, Wink, Borg, Frank ter, van Soest, Hanneke, Janssen, Harry L.A., Erler, Nicole S., van der Meer, Adriaan J., Abraham, Sunje, Aktas, Huseyin, Alderlieste, Yasser A., Aparicio-Pages, Maria N., Baven-Pronk, Martine A.M.C., van der Beek, A. (Sander), Bekkering, Frank C., Beukema, Menno, Boonstra, Kirsten, ter Borg, Frank, ter Borg, Pieter C.J., Bus, Paul J., Cazemier, Marcel, van Dam, Lisette J.H., Denters, Maaike J., Epping, Ludger S.M., Friederich, Philip W., van Gerven, Nicole F.M., Hansen, Bettina E., van den Hazel, Sven J., van Hooff, Maria C., Hotho, Daphne M., Kemenade, J.(Netty) van, Kerbert-Dreteler, Marjo J., Konings, Ingrid C.A.W., de Kort, Sander, Kuiper, Edith M.M., Kuyvenhoven, Johan P.H., Oterdoom, Leendert H., van Rooij, Janne E., Roomer, Robert, Schmidt-Böhmer, Johannes, Schmittgens, Stephan, Schreuder, Tim C.M.A., Nicolaas, Jerome Sint, van Stiphout, Stephan H.C., Thio, Hans H.K., Tielemans, Merel M., Vandebosch, Sigrid, Marleen de Vree, J., de Vries, Elsemieke, Vrieze, Anne, van der Waaij, Laurens A., de Wit, Ulrike
Format: Artikel
Sprache:eng
Schlagworte:
Incidence
Prevalence
Primary biliary cholangitis
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Zusammenfassung:Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time. On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged
ISSN:2589-5559
2589-5559
DOI:10.1016/j.jhepr.2024.101132