Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy

Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy

Dysbiosis and perturbations of fecal metabolic profiles have been reported in dogs with inflammatory bowel disease. Currently the incidence of dysbiosis and the fecal metabolomic profile in Yorkshire Terriers with chronic enteropathy (YTE) and the effects of treatment are unknown. This prospective o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2022-07, Vol.12 (1), p.12977-12977, Article 12977
Hauptverfasser: Galler, Alexandra I., Suchodolski, Jan S., Steiner, Joerg M., Sung, Chi-Hsuan, Hittmair, Katharina M., Richter, Barbara, Burgener, Iwan A.
Format: Artikel
Sprache:eng
Schlagworte:
692/4020
692/699
Bile
Bile acids
Dysbacteriosis
Fatty acids
Feces
Fusobacterium
Humanities and Social Sciences
Inflammatory bowel diseases
Metabolomics
multidisciplinary
Observational studies
Remission
Remission (Medicine)
Science
Science (multidisciplinary)
Sterols
Ursodeoxycholic acid
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Dysbiosis and perturbations of fecal metabolic profiles have been reported in dogs with inflammatory bowel disease. Currently the incidence of dysbiosis and the fecal metabolomic profile in Yorkshire Terriers with chronic enteropathy (YTE) and the effects of treatment are unknown. This prospective observational study analyzed the dysbiosis index (DI) and fecal bile acid, sterol and fatty acid profiles in 14 Yorkshire Terriers with active YTE, 11 dogs in clinical remission, and 26 healthy Yorkshire Terriers. YTE was associated with dysbiosis and a significant increase in fatty acids (docosanoate, p  = 0.002; gondoate, p  = 0.026; erucate, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17244-6