DNA mismatch repair in the context of chromatin

DNA mismatch repair in the context of chromatin

DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MM...

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Veröffentlicht in:Cell & bioscience 2020-02, Vol.10 (1), p.10-10, Article 10
Hauptverfasser: Huang, Yaping, Li, Guo-Min
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Biomarkers
Cancer
Cell division
Cells (Biology)
Chromatin
Deoxyribonucleic acid
DNA
DNA methylation
DNA polymerases
DNA repair
DNA-directed DNA polymerase
Gene expression
Genomes
Microsatellite instability
Mismatch repair
Mutation
Nucleotides
Pediatrics
Proteins
Review
Tumorigenesis
Tumors
Yeast
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Beschreibung
Zusammenfassung:DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-020-0379-7