INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial

INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial

Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design...

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Veröffentlicht in:Current controlled trials in cardiovascular medicine 2021-12, Vol.22 (1), p.885-885, Article 885
Hauptverfasser: Song, Lili, Chen, Chen, Chen, Xiaoying, Guo, Yijia, Liu, Feifeng, Lin, Yapeng, Billot, Laurent, Li, Qiang, Liu, Hueiming, Si, Lei, Ouyang, Menglu, Arima, Hisatomi, Bath, Philip M, Ford, Gary A, Robinson, Thompson, Sandset, Else Charlotte, Saver, Jeffrey L, Sprigg, Nikola, van der Worp, H Bart, Zhang, Chunfang, Yang, Jie, Li, Gang, Anderson, Craig S
Format: Artikel
Sprache:eng
Schlagworte:
Ambulance
Ambulance service
Ambulances
Antihypertensive Agents - therapeutic use
Blood Pressure
Care and treatment
Clinical trial
Clinical trials
Consent
Corporate sponsorship
Hematoma
Hemorrhage
Hospitals
Humans
Hypertension
Intervention
Management
Medical schools
Multicenter Studies as Topic
Pre-hospital
Prospective Studies
Quality of Life
Randomized Controlled Trials as Topic
Stroke
Stroke (Disease)
Stroke - drug therapy
Stroke - therapy
Study Protocol
Testing
Treatment Outcome
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Zusammenfassung:Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design of the fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4). A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed trial of pre-hospital BP lowering in 3116 hypertensive patients with suspected acute stroke at 50+ sites in China. Patients are randomized through a mobile phone digital system to intensive BP lowering to a target systolic BP of
ISSN:1745-6215
1745-6215
DOI:10.1186/s13063-021-05860-y