Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

BACKGROUNDAedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. METHOD...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2022-01, Vol.55, p.e00182022-e00182022
Hauptverfasser:	Garcia, Armando da Costa, Menezes Júnior, Orivaldo Teixeira de, Mariano, Lissa Apolonia, Santiago, Letícia Corrêa, Araújo, Ângela Regina, Monfardini, Julia Dietsche, Simões, Rejane de Castro, Oliveira, André Correa de, Roque, Rosemary Aparecida, Tadei, Wanderli Pedro, Teles, Helder Lopes, Oliveira, Camila Martins de
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomonitored chemical Dengue Secondary metabolite TROPICAL MEDICINE
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Zusammenfassung:	BACKGROUNDAedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. METHODSCrude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. RESULTSWe isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. CONCLUSIONSThe results indicated that 3-nitropropionic acid exerted larvicidal activity.
ISSN:	0037-8682 1678-9849 1678-9849
DOI:	10.1590/0037-8682-0018-2022