Photodynamic therapy combined with voriconazole of extensive ulcer caused by Trichosporon asahii

•A rare case of a massive ulcer caused by Trichosporon asahii in immunocompetent host.•Photodynamic therapy combined with voriconazole resulted in ulcer healing within a short time.•Provide the feasibility of ALA-PDT combined with drugs to treat refractory ulcers. Trichosporon species are part of the normal microbiota of humans which can cause both superficial and invasive infections, primarily affecting immunocompetent and immunocompromised hosts, respectively. Giant ulcer caused by Trichosporon asahii is relatively uncommon in immunocompetent hosts. Increased drug resistance and biofilm-associated virulence makes the treatment of infectious ulcers challenging. Herein, we present a case of a massive ulcer caused by T. asahii which resulted in completed healing when treated with photodynamic therapy (PDT) and voriconazole. It provided the feasibility for PDT combined with antifungal drugs to treat similar refractory cases.