Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Background: The effect of low-frequency functional variation on anti-tumor necrosis factor alpha (TNF) response in Crohn’s disease (CD) patients remains unexplored. The objective of this study was to investigate the impact of functional rare variants in clinical response to anti-TNF therapy in CD. M...

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Veröffentlicht in:Therapeutic advances in gastroenterology 2019, Vol.12, p.1756284819867848-1756284819867848
Hauptverfasser: Chaparro, María, Aterido, Adrià, Guerra, Iván, Iborra, Marisa, Cabriada, Jose Luis, Bujanda, Luis, Taxonera, Carlos, García-Sánchez, Valle, Marín-Jiménez, Ignacio, Barreiro-de Acosta, Manuel, Vera, Isabel, Martín-Arranz, Maria Dolores, Hernández-Breijo, Borja, Mesonero, Francisco, Sempere, Laura, Gomollón, Fernando, Hinojosa, Joaquín, Bermejo, Fernando, Beltrán, Belén, Rodríguez-Pescador, Ainhoa, Banales, Jesús María, Olivares, David, Aguilar-Melero, Patricia, Menchén, Luis, Ferreiro-Iglesias, Rocío, Blazquez Gómez, Isabel, Benitez García, Beatriz, Guijarro, Luis G, Marin, Alicia C, Bernardo, David, Marsal, Sara, Julia, Antonio, Gisbert, Javier P
Format: Artikel
Sprache:eng
Schlagworte:
Epigenetics
Gastroenterology
Genomes
Immunotherapy
Monoclonal antibodies
Original Research
TNF inhibitors
Tumor necrosis factor-TNF
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Zusammenfassung:Background: The effect of low-frequency functional variation on anti-tumor necrosis factor alpha (TNF) response in Crohn’s disease (CD) patients remains unexplored. The objective of this study was to investigate the impact of functional rare variants in clinical response to anti-TNF therapy in CD. Methods: CD anti-TNF naïve patients starting anti-TNF treatment due to active disease [Crohn’s Disease Activity Index (CDAI > 150)] were included. The whole genome was sequenced using the Illumina Hiseq4000 platform. Clinical response was defined as a CDAI score
ISSN:1756-2848
1756-283X
1756-2848
DOI:10.1177/1756284819867848