Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis

Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis

We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms. Bleomycin (BLM)-induced rats were respectively treated with 413.3, 826.6, and 1239.9 mg/kg of QFHXD and prednisone for 28 days. The lung tissues of rat...

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Veröffentlicht in:Iranian journal of basic medical sciences 2023-01, Vol.26 (1), p.107-113
Hauptverfasser: Li, Rui-Jie, Wu, Chao-Yan, Ke, Hao-Liang, Wang, Xiu-Ping, Zhang, Ying-Wen
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
extracellular matrix
lung diseases
nadph oxidases
Original
Oxidative stress
Pulmonary fibrosis
renin-angiotensin system
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Zusammenfassung:We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms. Bleomycin (BLM)-induced rats were respectively treated with 413.3, 826.6, and 1239.9 mg/kg of QFHXD and prednisone for 28 days. The lung tissues of rats were collected on day 28 for histological and western blotting analysis. QFHXD significantly reduced alveolus inflammation, collagen accumulation, and fibrosis deposition in BLM-induced PF rats (
ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2022.67042.14700