Brain imaging correlates of self- and other-reflection in schizophrenia

•Self- and other-reflection in schizophrenia were studied with fMRI.•Patients failed to activate the right temporo-parietal junction in other-reflection.•They also hyperactivated lateral prefrontal cortex for self and other-reflection.•These findings might be linked to altered self/other processing...

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Veröffentlicht in:NeuroImage clinical 2020-01, Vol.25, p.102134-102134, Article 102134
Hauptverfasser: Fuentes-Claramonte, Paola, Martin-Subero, Marta, Salgado-Pineda, Pilar, Santo-Angles, Aniol, Argila-Plaza, Isabel, Salavert, Josep, Arévalo, Antoni, Bosque, Clara, Sarri, Carmen, Guerrero-Pedraza, Amalia, Capdevila, Antoni, Sarró, Salvador, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond
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Sprache:eng
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Zusammenfassung:•Self- and other-reflection in schizophrenia were studied with fMRI.•Patients failed to activate the right temporo-parietal junction in other-reflection.•They also hyperactivated lateral prefrontal cortex for self and other-reflection.•These findings might be linked to altered self/other processing in schizophrenia. An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results. Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing. Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity. Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group.
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2019.102134