Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora

Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora

Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1–3 showed inhibitory activities...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-06, Vol.27 (13), p.4018
Hauptverfasser: Guo, Xia, Zhang, Yao, Xiao, Yin, Zhou, Lu, Yin, Shaoyang, Sheng, Xifeng, Xiang, Hongling, Zou, Hui
Format: Artikel
Sprache:eng
Schlagworte:
Callicarpa
Callicarpa nudiflora
Carbon
Cytotoxicity
Diterpenes
diterpenoids
Gastric cancer
Hepatocellular carcinoma
Lipopolysaccharides
Liver cancer
Nitric oxide
NMR
NO inhibitory effects
Nuclear magnetic resonance
Phytochemicals
seco-labdane diterpenoids
Spectrum analysis
Two dimensional analysis
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Zusammenfassung:Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1–3 showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds 1–2 exhibited more potent inhibitory activity than compound 3. The cytotoxicity of compounds 1–3 against human hepatocellular carcinoma HepG2 cells and human gastric carcinoma SGC-7901 cells were evaluated, while all of them exhibited no cytotoxicity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27134018