The Non-Invasive Prediction of Colorectal Neoplasia (NIPCON) Study 1995-2022: A Comparison of Guaiac-Based Fecal Occult Blood Test (FOBT) and an Anti-Adenoma Antibody, Adnab-9

The Non-Invasive Prediction of Colorectal Neoplasia (NIPCON) Study 1995-2022: A Comparison of Guaiac-Based Fecal Occult Blood Test (FOBT) and an Anti-Adenoma Antibody, Adnab-9

Given the need to improve the sensitivity of non-invasive methods to detect colorectal neoplasia, particularly adenomas, we compared a fecal test using a monoclonal antibody (Mab) raised against constituents of colonic adenomas designated Adnab-9 (Adenoma Antibody 9), recognizing an N-linked 87 kDa...

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Veröffentlicht in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17257
Hauptverfasser: Tobi, Martin, Antaki, Fadi, Rambus, Mary Ann, Yang, Yu-Xiao, Kaplan, David, Rodriguez, Rebecca, Maliakkal, Benedict, Majumdar, Adhip, Demian, Ereny, Tobi, Yosef Y, Sochacki, Paula, Ehrinpreis, Murray, Lawson, Michael G, McVicker, Benita
Format: Artikel
Sprache:eng
Schlagworte:
adenoma
Adenoma - diagnosis
Adnab-9
Antibodies
Antigens
Blood tests
Colon
Colonoscopy
Colonoscopy - methods
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - prevention & control
Early Detection of Cancer - methods
Effluents
fecal occult blood
Feces
Guaiac
Humans
Mass Screening - methods
Molecular weight
Occult Blood
p87
Polyps
Proteins
Sensitivity and Specificity
stool
Tumors
Urine
White people
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Zusammenfassung:Given the need to improve the sensitivity of non-invasive methods to detect colorectal neoplasia, particularly adenomas, we compared a fecal test using a monoclonal antibody (Mab) raised against constituents of colonic adenomas designated Adnab-9 (Adenoma Antibody 9), recognizing an N-linked 87 kDa glycoprotein, to gFOBT, which is shown to reduce CRC mortality. p87 immunohistochemistry testing is significantly more sensitive (OR 3.64[CI 2.37-5.58]) than gFOBT (guaiac-based fecal occult blood test) for adenomas (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242417257