Relationship between Serum Sirtuin 1 and Growth Hormone/Insulin-like Growth Factor 1 Concentrations in Children with Growth Hormone Deficiency and Idiopathic Short Stature

Sirtuin 1 (SIRT1) inhibits growth hormone (GH) intracellular signaling for the insulin-like growth factor 1 (IGF-1) synthesis via the janus kinase (JAK)/signal transducer and activator of transcription proteins (STATs) pathway. The aim of this study was to compare SIRT1 concentrations in children wi...

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Veröffentlicht in:	Biomedicines 2024-06, Vol.12 (7), p.1433
Hauptverfasser:	Fedorczak, Anna, Kowalik, Dorota, Kopciuch, Justyna, Głowacka, Ewa, Mikołajczyk, Katarzyna, Tkaczyk, Marcin, Lewiński, Andrzej, Stawerska, Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	Body height Body mass index Cell cycle Children Children & youth Gestational age growth hormone growth hormone deficiency Growth hormones Insulin insulin-like growth factor 1 Insulin-like growth factor I Insulin-like growth factor-binding protein 3 Insulin-like growth factors Intracellular signalling JAK/STATs pathway Janus kinase Kinases non-GH-deficient children Patients Puberty short stature SIRT1 protein
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Zusammenfassung:	Sirtuin 1 (SIRT1) inhibits growth hormone (GH) intracellular signaling for the insulin-like growth factor 1 (IGF-1) synthesis via the janus kinase (JAK)/signal transducer and activator of transcription proteins (STATs) pathway. The aim of this study was to compare SIRT1 concentrations in children with GH deficiency (GHD) and so-called idiopathic short stature (ISS, non-GH deficient), in order to determine the possible impact of changes in serum SIRT1 concentrations on the GH-IGF-1 axis. The study group included 100 short-stature children: 38 with GHD and 62 with ISS (maxGH in two stimulation tests
ISSN:	2227-9059 2227-9059
DOI:	10.3390/biomedicines12071433