Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Species from the genus L. have been used as healing agents for various ailments, with utilization of L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of and three related species, Lapeyr., L. and (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MS as the major metabolites of with known biological activities. demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant in the broth microdilution method (MIC = 1.42-3.79 mg/mL). also showed antibacterial activities against (MIC = 1.42 mg/mL), (MIC = 1.89 mg/mL), (MIC = 2.84 mg/mL) and (MBC = 5.68 mg/mL). , and showed greater anticancer potential than . Obtained results indicate investigated species could serve as sources of diverse bioactive molecules, with having the greatest antibacterial potential.