Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases

Supporting the argument, a recent study [4] showed that redox-active copper which accumulates in many neurodegenerative disease affected human brain regions, inhibits repair of genome damage by oxidizing cysteine residues in repair-initiating NEIL enzymes. [...]reversing this inhibitory effect not only requires a metal chelator, but also reducing, or natural compound like curcumin with dual activities. [6],[7] It is generally accepted that the primary pathology in AD involves oxidative stress, chronic inflammation and amyloid aggregation along with other secondary pathologies including genome damage and repair failure. [...]the study not only provides a proof-of-principle for AD prevention/therapy which would require a combination of anti-oxidant, anti-inflammatory and anti-amyloidogenic activity.