Simultaneous Endo-Epicardial Mapping of the Human Right Atrium: Unraveling Atrial Excitation

Background The significance of endo-epicardial asynchrony (EEA) and atrial conduction block (CB), which play an important role in the pathophysiology of atrial fibrillation (AF) during sinus rhythm is poorly understood. The aim of our study was therefore to examine 3-dimensional activation of the hu...

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Veröffentlicht in:Journal of the American Heart Association 2020-09, Vol.9 (17), p.e017069-e017069
Hauptverfasser: Kharbanda, Rohit K, Knops, Paul, van der Does, Lisette J M E, Kik, Charles, Taverne, Yannick J H J, Roos-Serote, Maarten C, Heida, Annejet, Oei, Frans B S, Bogers, Ad J J C, de Groot, Natasja M S
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Sprache:eng
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Zusammenfassung:Background The significance of endo-epicardial asynchrony (EEA) and atrial conduction block (CB), which play an important role in the pathophysiology of atrial fibrillation (AF) during sinus rhythm is poorly understood. The aim of our study was therefore to examine 3-dimensional activation of the human right atrium (RA). Methods and Results Eighty patients (79% men, 39% history of AF) underwent simultaneous endo-epicardial sinus rhythm mapping of the inferior, middle and superior RA. Areas of CB were defined as conduction delays of ≥12 ms, EEA as activation time differences of opposite electrodes of ≥15 ms and transmural CB as CB at similar endo-epicardial sites. CB was more pronounced at the endocardium (all locations
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.120.017069