Beyond the Brain

Beyond the Brain

Objective:Given the emerging data suggesting the key role of brain-derived neurotrophic factor (BDNF) in the immune system, we assessed longitudinally whether BDNF depletions induced by hazardous alcohol use (HAU) would impact a response to antiretroviral therapy (ART).Methods:In a prospective singl...

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Veröffentlicht in:Journal of the International Association of Providers of AIDS Care 2014-09, Vol.13 (5), p.454-460
Hauptverfasser: Míguez-Burbano, María José, Espinoza, Luis, Bueno, Diego, Vargas, Mayra, Trainor, Allison B, Quiros Clery, Lewis, John E, Asthana Deshratn
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol use
Antiretroviral drugs
Antiretroviral therapy
Brain
Brain-derived neurotrophic factor
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Beschreibung
Zusammenfassung:Objective:Given the emerging data suggesting the key role of brain-derived neurotrophic factor (BDNF) in the immune system, we assessed longitudinally whether BDNF depletions induced by hazardous alcohol use (HAU) would impact a response to antiretroviral therapy (ART).Methods:In a prospective single-site cohort, virological and immunological responses to ART in 200 hazardous and 200 nonhazardous users were obtained, along with plasma BDNF levels.Results:Hazardous drinkers were more likely to have BDNF levels
ISSN:2325-9574
2325-9582
DOI:10.1177/2325957414535253