In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication

(1) Background: Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2) Method...

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Veröffentlicht in:Foods 2022-02, Vol.11 (5), p.694
Hauptverfasser: Hajdrik, Polett, Pályi, Bernadett, Kis, Zoltán, Kovács, Noémi, Veres, Dániel Sándor, Szigeti, Krisztián, Budán, Ferenc, Hegedüs, Imre, Kovács, Tibor, Bergmann, Ralf, Máthé, Domokos
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Sprache:eng
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Zusammenfassung:(1) Background: Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2) Methods: Here, the antiviral activity of a humic substance containing ascorbic acid, Se and Zn ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern ("Alpha Variant") in a VeroE6 cell line. (3) Results: This combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. (4) Conclusions: Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods11050694