Integrated analysis of antibiotic consumption in the hospital segment of Saint-Petersburg in 2014–2018

Objective. To estimate composite indicators of systemic antibiotic consumption in the hospital segment of Saint-Petersburg in 2014–2018. Materials and Methods. Information on the volume and structure of AMP consumption in the hospital segment of St. Petersburg in 2014–2018 was obtained from AlfaRm Databases. The amount of purchased AMP was recalculated in the number of average daily maintenance doses (Defined Daily Dose, DDDs), as well as DDDs per 100 bed-days (DDDh) for each international nonproprietary name of AMP. Data on the bed-days spent in the period 2014–2018, as well as the epidemiological situation in hospitals of St. Petersburg in the period 2016–2018 were obtained from the databases of St. Petersburg state medical institution MIAC. Based on data on AMP consumption and the epidemiological situation in hospitals in St. Petersburg, the indicator of a comprehensive assessment of AMP consumption – the drug resistance index (DRI) was calculated. Results. During the study, there was a decrease in the absolute consumption of AMP from 17.6 to 9.2 million DDDs, with a decrease in DDDh from 125 to 66, accompanied by a decrease in the total cost of purchasing AMP from 74 to 67 million rubles per year. Fluoroquinolones, other AMP and cephalosporins remained the main classes of AMP for systemic use throughout the observation period. At the same time, the relative amounts of resistant strains of the ESKAPE group of bacteria, as well as DRI, remained virtually unchanged. Conclusions. Pharmacoepidemiological monitoring data provide a picture of current trends in the use of AMP and can serve as a guide for the treatment of patients, identifying risk groups, informing policy makers and used to assess the effectiveness of measures taken.