Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Targeting CCL2-CCR2 Signaling Axis in Cancer Therapy

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes. Many studies have shown that the CCL2-CCR2 axis pro...

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Veröffentlicht in:Zhongliu fangzhi yanjiu 2019-05, Vol.46 (5), p.470-475
Hauptverfasser: Lu, Xiaomei, Fu, Jiejun
Format: Artikel
Sprache:chi
Schlagworte:
Angiogenesis
Biological activity
Breast cancer
Cancer
Cancer therapies
CC chemokine receptors
ccl2
ccr2
CCR2 protein
Clinical trials
Liver cancer
Lymphocytes
Lymphocytes T
Macrophages
Medical research
Metastases
Metastasis
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Monocytes
Prostate cancer
targeting
Therapy
tumor
Tumor cells
Tumors
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Zusammenfassung:Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the CC chemokine family. CCL2 plays a crucial role in a wide range of biological processes. CCL2 mainly binds to its receptor CCR2 and recruits monocytes, macrophages and T lymphocytes. Many studies have shown that the CCL2-CCR2 axis promotes tumor cells growth and survival, angiogenesis, tumor invasion and metastasis. This review summarizes the role of CCL2-CCR2 axis in the development, progression and metastasis of prostate cancer, breast cancer and liver cancer, as well as the progress, prospects and challenges of clinical trials in targeting CCL2-CCR2 axis in tumor therapy.
ISSN:1000-8578
1000-8578
DOI:10.3971/j.issn.1000-8578.2019.18.1237