Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk

Breast cancer is a multifactorial disease in which the interplay among multiple risk factors remains unclear. Energy homeostasis genes play an important role in carcinogenesis and their interactions with the serum concentrations of IGF-1 and IGFBP-3 on the risk of breast cancer have not yet been inv...

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Veröffentlicht in:	Scientific reports 2022-02, Vol.12 (1), p.1837-1837, Article 1837
Hauptverfasser:	Rodríguez-Valentín, Rocío, Torres-Mejía, Gabriela, Martínez-Matsushita, Louis, Angeles-Llerenas, Angélica, Gómez-Flores-Ramos, Liliana, Wolff, Roger K., Baumgartner, Kathy B., Hines, Lisa M., Ziv, Elad, Flores-Luna, Lourdes, Sánchez-Zamorano, Luisa Ma, Ortiz-Panozo, Eduardo, Slattery, Martha L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2490 631/67/1347 692/700/478/174 Adult Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinogenesis Case-Control Studies Energy Energy balance Energy Metabolism - genetics Female Genetic Association Studies Genetic diversity Health risks Homeostasis Humanities and Social Sciences Humans Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factor-binding protein 3 Middle Aged multidisciplinary Neuropeptide Y Polymorphism, Single Nucleotide Predictive Value of Tests Premenopause Risk Assessment Risk Factors Science Science (multidisciplinary) Single-nucleotide polymorphism United States
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Zusammenfassung:	Breast cancer is a multifactorial disease in which the interplay among multiple risk factors remains unclear. Energy homeostasis genes play an important role in carcinogenesis and their interactions with the serum concentrations of IGF-1 and IGFBP-3 on the risk of breast cancer have not yet been investigated. The aim of this study was to assess the modifying effect of the genetic variation in some energy homeostasis genes on the association of serum concentrations of IGF-1 and IGFBP-3 with breast cancer risk. We analyzed 78 SNPs from 10 energy homeostasis genes in premenopausal women from the 4-Corner’s Breast Cancer Study (61 cases and 155 controls) and the Mexico Breast Cancer Study (204 cases and 282 controls). After data harmonization, 71 SNPs in HWE were included for interaction analysis. Two SNPs in two genes ( MBOAT rs13272159 and NPY rs16131) showed an effect modification on the association between IGF-1 serum concentration and breast cancer risk ( P interaction
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-05496-1