Sleep quality and cerebrospinal fluid oxysterols in degenerative dementias: correlations and possible biomedical implications

Objective: The combination and tentative correlation of a selected set of polysomnographic tests with the quantitative measurement of oxysterols of pathophysiological relevance in the cerebrospinal fluid (CSF) of patients with Alzheimer’s degenerative dementia (AD), non-Alzheimer’s degenerative dementia (NAD) and nondegenerative disorders (C) were afforded in a pilot study. Methods: Sleep efficiency, percentage of sleep time spent in nonrapid eye movement (NREM) stage 3 (N3), apnea/hypopnea index and sleep time spent with oxygen saturation