Biologic Therapy and Severe Asthma in Children

Biologic Therapy and Severe Asthma in Children

Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have...

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Veröffentlicht in:Biomedicines 2021-06, Vol.9 (7), p.760
Hauptverfasser: Russo, Daniele, Di Filippo, Paola, Attanasi, Marina, Lizzi, Mauro, Di Pillo, Sabrina, Chiarelli, Francesco
Format: Artikel
Sprache:eng
Schlagworte:
Allergens
Allergic diseases
Allergies
Antigens
Asthma
biologic therapy
Children
Clinical trials
Cloning
Cytokines
Drug dosages
endotype
FDA approval
Inflammation
Monoclonal antibodies
Multiple myeloma
Neutrophils
Pediatrics
phenotype
Review
severe asthma
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Beschreibung
Zusammenfassung:Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have been developed. Due to their precise ability to target specific inflammatory type 2 mediators, biologics have revolutionized the care of chronic allergic diseases in the pediatric and adult population. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat severe asthma in children and adolescents.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9070760