Correlation of 2 hours and 24 hours creatinine clearance in renal donors after unilateral nephrectomy

The kidney performs numerous specialised functions in an effort to maintain constancy of the internal composition of body fluids. This study was done to ascertain the feasibility of estimating creatinine clearance as an outpatient procedure over a 2 hours period instead of doing the study over a 24 hours period. Eighteen renal donors, Twelve females and Six males, who were closely related to recipients, were chosen. This study was done on renal donors who attended the Nephrology Department of Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai-03 India. To estimate creatinine clearance in 24 hours urine, 24 hours urine sample was collected from 9 am on the first day to 9 am on the next day, after first emptying the bladder. Then, creatinine clearance was calculated by using standard formula, CC=UV/ Pt X 1.73m(2)/BSA of the individual. There was no significant differences in mean creatinine clearance values by collecting 2 hours and 24 hours urine samples from renal donors in different stages of post nephrectomy period. It has been shown that 2 hours collection of urine sample is as good as 24 hours urine sample for estimating creatinine clearance. Hence it was proved that measurement of creatinine clearance could be done as an outpatient procedure, as the patient needed only 2 hours of hospital stay.