Association between antecedent infection and albuminocytologic dissociation in cerebrospinal fluid of patients with Guillain-Barré syndrome

Objective To analyze the albuminocytologic dissociation in cerebrospinal fluid （CSF） and differences in CSF protein levels in Guillain-Barré syndrome （GBS）patients with various types of antecedent infections and investigate the correlation between antecedent infections and increased CSF protein levels in GBS patients. Methods Clinical data and CSF analysis results of 198 GBS patients were collected. Enzyme-linked immunosorbent assay （ELISA） was employed to detect 14 types of infectious pathogens in the serum of GBS patients. The proportion of albuminocytologic dissociation and the differences in CSF protein levels were analyzed in GBS patients with different antecedent infections. Results In total，55.1% （109/198） of GBS patients had serological positivity for infectious pathogens，23.7% （47/198） for Campylobacter jejuni，20.7% （41/198） for Influenza A virus，15.2% （30/198） for Influenza B virus. Among them，18.7% （37/198） of GBS patients had serological positivity for two or more pathogens. In total，73.7% （146/19