miR-99a-5p inhibits target gene FZD5 expression and steroid hormone secretion from goat ovarian granulosa cells

miR-99a-5p inhibits target gene FZD5 expression and steroid hormone secretion from goat ovarian granulosa cells

MicroRNA (miRNA) has vital regulatory effects on the proliferation, differentiation and secretion of ovarian granulosa cells, but the role of miR-99a-5p in goat ovarian granulosa cells (GCs) is unclear. Both miR-99a-5p and Frizzled-5 (FZD5) were found to be expressed in GCs in goat ovaries via fluor...

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Veröffentlicht in:Journal of Integrative Agriculture 2022-04, Vol.21 (4), p.1137-1145
Hauptverfasser: ZHU, Lu, JING, Jing, QIN, Shuai-qi, LU, Jia-ni, ZHU, Cui-yun, ZHENG, Qi, LIU, Ya, FANG, Fu-gui, LI, Yun-sheng, ZHANG, Yun-hai, LING, Ying-hui
Format: Artikel
Sprache:eng
Schlagworte:
estradiol, progesterone
follicular development
Frizzled-5
miRNA
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Zusammenfassung:MicroRNA (miRNA) has vital regulatory effects on the proliferation, differentiation and secretion of ovarian granulosa cells, but the role of miR-99a-5p in goat ovarian granulosa cells (GCs) is unclear. Both miR-99a-5p and Frizzled-5 (FZD5) were found to be expressed in GCs in goat ovaries via fluorescence in situ hybridization and immunohistochemistry, respectively, and FZD5 was verified (P
ISSN:2095-3119
2352-3425
DOI:10.1016/S2095-3119(21)63766-8