ABO Mismatch in Allogeneic Hematopoietic Stem Cell Transplant: Effect on Short- and Long-term Outcomes

ABO Mismatch in Allogeneic Hematopoietic Stem Cell Transplant: Effect on Short- and Long-term Outcomes

The impact of ABO incompatibility (ABO-I) on hematopoietic stem cell transplant outcomes is still debated. We retrospectively investigated 432 consecutive transplants performed at our center (2012-2020). All patients but 6 were affected by hematologic malignancies. The effect of different ABO match...

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Veröffentlicht in:Transplantation direct 2021-08, Vol.7 (8), p.e724-e724
Hauptverfasser: Valentini, Caterina Giovanna, Metafuni, Elisabetta, Gallo, Lorenzo, Giammarco, Sabrina, Orlando, Nicoletta, Bianchi, Maria, Sica, Simona, Bacigalupo, Andrea, Chiusolo, Patrizia, Teofili, Luciana
Format: Artikel
Sprache:eng
Schlagworte:
Bone Marrow and Stem Cell Transplantation
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Zusammenfassung:The impact of ABO incompatibility (ABO-I) on hematopoietic stem cell transplant outcomes is still debated. We retrospectively investigated 432 consecutive transplants performed at our center (2012-2020). All patients but 6 were affected by hematologic malignancies. The effect of different ABO match combinations on engraftment rate, transfusion support, acute and chronic graft-versus-host disease incidences, nonrelapse mortality (NRM), disease-free survival, and overall survival was assessed in univariate and multivariate analysis. Significance was set at  
ISSN:2373-8731
2373-8731
DOI:10.1097/TXD.0000000000001179