Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A ( ) and 2,2-dioxidothiolutin ( ), together with the kn own compound, thiolutin ( ) were identified from a marine-derived sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China....

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Veröffentlicht in:	Marine drugs 2022-03, Vol.20 (3), p.214
Hauptverfasser:	Song, Fuhang, Hu, Jiansen, Zhang, Xinwan, Xu, Wei, Yang, Jinpeng, Li, Shaoyong, Xu, Xiuli
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology antibacterial Antibacterial activity Antibiotics Aquatic Organisms - chemistry Aquatic Organisms - genetics Biological Products - chemistry Biological Products - isolation & purification Biological Products - pharmacology Candida albicans - drug effects Candida albicans - growth & development Coastal zone Communication Cyclization Drug resistance E coli Escherichia coli Gram-positive bacteria M. tuberculosis marine-derived Streptomyces Metabolites Microbial Sensitivity Tests Microorganisms Minimum inhibitory concentration NMR Nuclear magnetic resonance Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology Spectrum analysis Staphylococcus aureus Streptomyces Streptomyces - chemistry Streptomyces - genetics Sulfur Sulphur thiolopyrrolone Tuberculosis
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Zusammenfassung:	Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A ( ) and 2,2-dioxidothiolutin ( ), together with the kn own compound, thiolutin ( ) were identified from a marine-derived sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against , , Bacille Calmette-Guérin (BCG), , and . displayed antibacterial activities against BCG, , and with minimum inhibitory concentration (MIC) values of 10, 10, and 100 μg/mL, respectively. Thiolutin ( ) showed antibacterial activities against , BCG, , and with MIC values of 6.25, 0.3125, 0.625, and 3.125 μg/mL, respectively.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md20030214