Survivin expression in canine spontaneous cutaneous and subcutaneous tumors and its prognostic importance

The present study was carried out to know the expression level of survivin, an inhibitor of apoptosis protein with an objective to determine its prognostic importance in cutaneous and subcutaneous tissue tumors of dogs. Forty cases of canine cutaneous and subcutaneous tissue tumors on histopathologi...

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Veröffentlicht in:Veterinary World 2017-10, Vol.10 (10), p.1286-1291
Hauptverfasser: Kavya, N, Rao, S, Sathyanarayana, M L, Narayanaswamy, H D, Byregowda, S M, Ranganath, L, Kamaran, A, Purushotham, K M, Kishore, T K
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Sprache:eng
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Zusammenfassung:The present study was carried out to know the expression level of survivin, an inhibitor of apoptosis protein with an objective to determine its prognostic importance in cutaneous and subcutaneous tissue tumors of dogs. Forty cases of canine cutaneous and subcutaneous tissue tumors on histopathological examination revealed various round cell, epithelial, and mesenchymal cell tumors. Survivin gene expression was detected in all tumors tested by TaqMan real-time polymerase chain reaction assay by comparative cycle threshold method. The mean survivin gene expression value of benign tumors was 0.94±0.63 folds and that of malignant tumors was 18.87±5.30 folds. Postsurgical follow up of 30 malignant tumor cases revealed death in 8, recurrence in 7, and neoplastic free alive status in 15 dogs with mean survivin fold difference values of 48.49±12.39, 14.63±6.37, and 5.034±2.27, respectively. The mean survivin gene expression value was significantly higher in malignant (30 cases, 18.87±5.30) compared to benign tumors (10 cases, 0.94±0.63), and it varied between various postsurgical follow-up groups (p
ISSN:0972-8988
2231-0916
DOI:10.14202/vetworld.2017.1286-1291