Condition-Dependent Neural Dimensions Progressively Shift during Reach to Grasp

Neural population space analysis was performed to assess the dimensionality and dynamics of the neural population in the primary motor cortex (M1) during a reach-grasp-manipulation task in which both the reach location and the object being grasped were varied. We partitioned neural activity into three components: (1) general task-related activity independent of location and object, (2) location- and/or object-related activity, and (3) noise. Neural modulation related to location and/or object was only one-third the size of either general task modulation or noise. The neural dimensions of location and/or object-related activity overlapped with both the general task and noise dimensions. Rather than large amplitude modulation in a fixed set of dimensions, the active dimensions of location and/or object modulation shifted progressively over the time course of a trial. [Display omitted] •Neural modulation related to location and/or object is smaller than general task modulation•Neural dimensions of location and/or object overlap with those of the general task•Neural dimensions of location and/or object modulation shift as a trial progresses in time•Noise is large but evenly distributed across neural dimensions and time Rouse and Schieber show that during reach-grasp-manipulate movements, M1 activity related to location and object occurs not in a fixed set but rather in a shifting set of neural dimensions that overlap with those of general task and noise activity.