Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutatio...

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Veröffentlicht in:Emerging infectious diseases 2021-05, Vol.27 (5), p.1522-1524
Hauptverfasser: Nonaka, Carolina K V, Franco, Marília Miranda, Gräf, Tiago, de Lorenzo Barcia, Camila Araújo, de Ávila Mendonça, Renata Naves, de Sousa, Karoline Almeida Felix, Neiva, Leila M C, Fosenca, Vagner, Mendes, Ana V A, de Aguiar, Renato Santana, Giovanetti, Marta, de Freitas Souza, Bruno Solano
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Case studies
coronavirus disease
Coronaviruses
COVID-19
Diseases
Epidemiology
Genomes
Hospitals
Infections
Microbial mutation
Mutation
Phylogenetics
Relapse
Research Letter
respiratory infections
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral infections
viruses
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Zusammenfassung:Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2705.210191