Analysis of prevailing pertussis strains from different regions in China after the application of acellular vaccines

[...]199 isolated B. pertussis strains were used for phylogenetic analysis, including 100 strains from Tianjin, 49 from Xi’an, and 50 from Shenzhen, all reported after ACV uptake. The sequences of B. pertussis isolates from Tianjin are relatively evenly distributed throughout the development tree, and their clustering is not as obvious as those of the isolates from Xi’an or Shenzhen [Figure 1]. [...]the correlation between strains from Tianjin is not as close as that of those from Shenzhen in 2018. [...]there is no expanded study on the relationship between ptxP3 and A2047G. [...]the evolution of B. pertussis strains after ACV uptake differed among three regions of China, and the mismatch between the prevailing strains in different regions and the CS strain may explain the current pertussis resurgence.