Isosorbide, a versatile green chemical: Elucidating its ADME properties for safe use

Isosorbide, an environmentally friendly and renewable substance, finds extensive application in diverse fields, such as a bisphenol A substitute, polymers, functional materials, organic solvents, fuels, and pharmaceuticals. Despite its increasing interest and widespread usage, there remains a notable absence of available reports regarding its absorption, distribution, metabolism, and excretion (ADME) properties. This study endeavors to investigate the ADME characteristics of isosorbide in rats. Isosorbide levels in biological samples were quantified based on the analytical method using gas chromatography-mass spectrometry (GC-MS). Following administration, isosorbide exhibited rapid absorption and elimination, with a bioavailability of 96.1%. The metabolic stability assay indicated that isosorbide remained stable during metabolism. The majority of absorbed isosorbide was promptly excreted, with urinary excretion as the primary route. This study furnishes valuable insights into the ADME of isosorbide, contributing to its safety assessment and fostering its continued application across various domains. [Display omitted] •ADME profiles of isosorbide were investigated both in vitro and in vivo.•Development of a simple and robust GC-MS method to determine the isosorbide in biological matrices.•Isosorbide was rapidly absorbed, distributed, stable to metabolism, and excreted mainly via urine within 24 h.•Isosorbide possesses favorable ADME profiles indicating its suitability as a green chemical.