Proteomic profiling identifies markers for inflammation-related tumor-fibroblast interaction

Cancer associated fibroblasts are activated in the tumor microenvironment and contribute to tumor progression, angiogenesis, extracellular matrix remodeling, and inflammation. To identify proteins characteristic for fibroblasts in colorectal cancer we used liquid chromatography-tandem mass spectrome...

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Veröffentlicht in:	Clinical proteomics 2017-10, Vol.14 (1), p.33-33, Article 33
Hauptverfasser:	Drev, Daniel, Bileck, Andrea, Erdem, Zeynep N, Mohr, Thomas, Timelthaler, Gerald, Beer, Andrea, Gerner, Christopher, Marian, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Bioinformatics Biological markers Cancer Cancer associated fibroblasts Collagen Colorectal cancer Colorectal carcinoma Cysteine Extracellular matrix Extracellular matrix organization Feasibility studies Fibroblasts Gene expression Genetic aspects Growth factors Immunohistochemistry Inflammation Inflammation signature Liquid chromatography Localization Mass spectrometry Mass spectroscopy Medical prognosis Metastasis mRNA Mucosa Osteonectin Proteins Proteomics Rodents SPARC Stroma THBS2 Thrombospondin Tissues Transforming growth factor-b Transforming growth factor-b1 Tumors
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Zusammenfassung:	Cancer associated fibroblasts are activated in the tumor microenvironment and contribute to tumor progression, angiogenesis, extracellular matrix remodeling, and inflammation. To identify proteins characteristic for fibroblasts in colorectal cancer we used liquid chromatography-tandem mass spectrometry to derive protein abundance from whole-tissue homogenates of human colorectal cancer/normal mucosa pairs. Alterations of protein levels were determined by two-sided t test with greater than threefold difference and an FDR of
ISSN:	1542-6416 1559-0275
DOI:	10.1186/s12014-017-9168-7