Diagnostic value of 3D volume measurement of central pulmonary artery based on CTPA images in the pulmonary hypertension

This retrospective study aims to evaluate the diagnostic value of volume measurement of central pulmonary arteries using computer tomography pulmonary angiography (CTPA) for predicting pulmonary hypertension (PH). A total of 59 patients in our hospital from November 2013 to April 2021 who underwent both right cardiac catheterization (RHC) and CTPA examination were included. Systolic pulmonary artery pressure (SPAP), mean PAP (mPAP), and diastolic PAP (DPAP) were acquired from RHC testing. Patients were divided into the non-PH group (18 cases) and the PH group (41 cases). The diameters of the main pulmonary artery (D ), right pulmonary artery (D ), and left pulmonary artery (D ) were measured manually. A 3D model software was used for the segmentation of central pulmonary arteries. The cross-sectional areas (A , A , A ) and the volumes (V , V , V ) were calculated. Measurements of the pulmonary arteries derived from CTPA images were compared between the two groups, and correlated with the parameters of RHC testing. ROC curves and decision curve analysis (DCA) were used to evaluate the benefit of the three-dimensional CTPA parameters for predicting PH. A multiple linear regression model with a forward-step approach was adopted to integrate all statistically significant CTPA parameters for PH prediction. All parameters (D , D , D , A , A , A V , V , and V ) of CTPA images exhibited significantly elevated in the PH group in contrast to the non-PH group (P