The role of bone marrow microenvironment in the progression of multiple myeloma from monoclonal gammopathy of undetermined significance

Multiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associ...

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Veröffentlicht in:Onkogematologii͡a 2021-09, Vol.16 (3), p.26-32
Hauptverfasser: Khudovekova, A. S., Rudenko, Ya. A., Dorosevich, A. E.
Format: Artikel
Sprache:eng ; rus
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Zusammenfassung:Multiple myeloma is a tumor of plasma cells, one of the most common malignant blood diseases. It is preceded by a stage called monoclonal gammopathy of undetermined significance, from which true multiple myeloma develops in only a small percentage of cases. It was assumed that this process is associated with the accumulation of genetic mutations, but in recent years there is increasing evidence that the bone marrow microenvironment plays a key role in progression and that it can become a target for therapy that prevents the myeloma development. The review considers the role of mesenchymal stem cells, immune system cells, endotheliocytes, fibroblasts, adipocytes, osteoclasts and osteoblasts in multiple myeloma progression, as well as the impact of the sympathetic nervous system and microbiome composition.
ISSN:1818-8346
2413-4023
DOI:10.17650/1818-8346-2021-16-3-26-32